Restrictions for GRE IPv6 Tunnels
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Keepalive is not supported over GRE IPv6 Tunnels, whereas it is supported over GRE IPv4 Tunnels.
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ISIS is not supported over GRE tunnels.
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Checksum is supported over GRE IPv6 Tunnels but not over GRE IPv4 Tunnels.
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MPLS over GRE IPv6 Tunnel is not supported whereas GRE IPv6 Tunnel over MPLS is supported.
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No feature interactions such as IPSec, ACL, Tunnel counters, Crypto support, Fragmentation, Cisco Discovery Protocol (CDP), QoS, GRE keepalive, etc. are supported on GRE tunnels.